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As one of Virginia Tech's research investment institutes, ISCE supports innovative, interdisciplinary and translational research that addresses critical human and societal concerns impacting the lives of people and places. ISCE's four thematic areas of research and scholarship include:

• Global Issues Initiative:  global trade and economic integration; global security; public policy; counter-terrorism; public health; science policy
• Human Development and Health: life span issues; aging issues; children, adolescents, adulthood, family, community; child and adult health behavior; social influences on health; public health; health policy
• Risk and Resilience:  individual risk; social complexity, ethics; risk analysis; disaster management; social media and communication; technology, security; public policy
• Community and Built Environments: urban formations; rural settings; home environments; policy implementation and evaluation